17beta hydroxysteroid dehydrogenase type 1

ERα/ERβ are in inactive state trapped in multimolecular chaperone complexes organized around the heat shock protein 90 (HSP90), containing p23 protein, and immunophilin, and located in majority in cytoplasm and partially in nucleus. In the E2 classical pathway or estrogen classical pathway, estradiol enters the cytoplasm , where it interacts with ERs. Once bound E2, ERs dissociate from the molecular chaperone complexes and become competent to dimerize, migrate to nucleus, and to bind to specific DNA sequences ( estrogen response element , ERE), allowing for gene transcription which can take place over hours and days.

17beta hydroxysteroid dehydrogenase type 1

17beta hydroxysteroid dehydrogenase type 1

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17beta hydroxysteroid dehydrogenase type 117beta hydroxysteroid dehydrogenase type 117beta hydroxysteroid dehydrogenase type 117beta hydroxysteroid dehydrogenase type 117beta hydroxysteroid dehydrogenase type 1