Perhaps the most dramatic effect, which was not foreseen at the time when the anti-IgE therapy was designed and which was discovered during the clinical trials, is that as the free IgE in patients is depleted by omalizumab, the FcεRI receptors on basophils, mast cells, and dendritic cells are gradually down-regulated with somewhat different kinetics, rendering those cells much less sensitive to the stimulation by allergens.    Thus, in this regard, therapeutic anti-IgE antibodies represent a new class of potent mast cell stabilizers ,  providing the fundamental mechanism for omalizumab's effects on various allergic and non-allergic diseases involving mast cell degranulation. Many investigators have identified or elucidated a host of pharmacological effects, which help bring down the inflammatory status in the omalizumab-treated patients.   
Allergic contact dermatitis (reaction to temporary tattoo ). Contact allergy to temporary tattoos has become an increasingly common phenomenon. In most cases, the tattoo material does not contain pure henna, but is a mixture of brown henna with paraphenylenediamine (PPD) called black henna. The patient is allergic to PPD in the tattoo. In fact, the concentration of PPD in black henna is higher than that seen in commercial hair dyes. After resolution of the eczematous skin eruption, postinflammatory hyperpigmentation may persist for a considerable period of time.
Diagnosis Index entries containing back-references to :