The structure of cyclocreatine is fairly flat (planar), which aids in passive diffusion across membranes. It has been used with success in an animal study, where mice suffered from a SLC6A8 (creatine transporter at the blood brain barrier) deficiency, which is not responsive to standard creatine supplementation.  This study failed to report increases in creatine stores in the brain, but noted a reduction of mental retardation associated with increased cyclocreatine and phosphorylated cyclocreatine storages.  As demonstrated by this animal study and previous ones, cyclocreatine is bioactive after oral ingestion   and may merely be a creatine mimetic, able to phosphorylate ADP via the creatine kinase system. 
Someone said they don't prescribe Advair in the us anymore. Not true. My dr. Prescribed that for me today but with insurance cost just under $400!!! I don't understand how they get away with this! Needless to say I couldn't afford that much money. I was told there was not a generic for this. My previous Dr. Prescribed albeuterol but didn't work well. He dr today said he wanted to try a different kind of inhaler hense the advair script. Does anyone know of an inhaler that works like advair and doesn't cost as much as my health insurance costs monthly?
I just wanted to share that my partner and I moved from Canada to Greece in pursuit of the best olive oil. What happened is we discovered the research of Drs. Magiatis and Melliou at the University of Athens into the medicinal benefits of high phenolic extra virgin olive oil. The short story is that we are now involved in the research and testing of high phenolic olive oil using our own in the field test kit for growers invented by Magiatis/Melliou. This kit is based on the sophisticated science of Nuclear Magnetic Resonance (NMR) and olive oils are tested and certified with the complete phenolic profile once sorted for quality.