Concommitent drug intake should be carefully scrutinized prior to prescribing or injecting a corticosteroid. A number of drug interactions have been reported that often potentiate or diminish the drugs clearance and half-lives. Non-steroidal anti-inflammatory drugs, oral contraceptives and other exogenous estrogens are known to increase the potency of corticosteroids. Macrolide antibiotics such as erythromycin and azithromycin may increase the potency of methylprednisolone by decreasing its clearance. In contrast rifampin, phenobarbital, carbamazepine, and phenytoin often increase drug clearance and decrease the anti-inflammatory effect of the corticosteroid. Oral anti-coagulants and theophylline have varying effects. 15 The physician would be prudent in making doseage adjustments accordingly when patients are discovered to be consuming these drugs.
It is important to use the correct amount of topical steroid for your eczema, as instructed by your healthcare professional. Topical steroids should be applied with clean hands so that the skin just glistens. It can sometimes be difficult to judge how much steroid to use and there are guidelines on the amount required to cover body areas that are affected by eczema. These are based on the Finger Tip Unit (FTU), and explained in detail in our fact sheet which you can download as a pdf from the related documents to the right of this page.
This information should not be used to decide whether or not to take Aclovate or any other medicine. Only the healthcare provider has the knowledge and training to decide which medicines are right for a specific patient. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to Aclovate. This information is not specific medical advice and does not replace information you receive from the healthcare provider. You must talk with the healthcare provider for complete information about the risks and benefits of using this medicine.