Addiction to cortisone was the subject of the 1956 motion picture, Bigger Than Life , produced by and starring James Mason . Though it was a box-office flop upon its initial release,  many modern critics hail it as a masterpiece and brilliant indictment of contemporary attitudes towards mental illness and addiction.  In 1963, Jean-Luc Godard named it one of the ten best American sound films ever made.  John F. Kennedy needed to regularly use corticosteroids such as cortisone as a treatment for Addison's Disease . 
What is cortisone?
It is a hormone produced by a small gland on top of the kidney called the adrenal gland. It is essential to the proper functioning of your body, particularly when under stress. Its absence is known as Addison's Disease, which without treatment is fatal. Cortisone is a normal body product therefore; there are no allergic reactions. In cases of people with severe allergies, it is one of our most effective treatment tools. Cortisone by itself is rarely used today as it is relatively short acting and of low potency. Semi-artificial cortisone derivatives, such as DepoMedrol, Celestone, Kenalog, and a number of others, are used with increased benefits and fewer side effects.