Decongestant nasal sprays and eye drops often contain oxymetazoline and are used for topical decongestion . Pseudoephedrine acts indirectly on the adrenergic receptor system, whereas phenylephrine and oxymetazoline are direct agonists . The effects are not limited to the nose, and these medicines may cause hypertension (high blood pressure) through vasoconstriction ; it is for this reason that people with hypertension are advised to avoid them. Most decongestants, however, are not pronounced stimulants, due to lack of response from the other adrenoreceptors. Besides hypertension, common side-effects include sleeplessness, anxiety, dizziness, excitability, and nervousness.
Children under six years, women who are pregnant or nursing, and people who have had an allergic reaction to Afrin (oxymetazoline) shouldn't use it. This medication should be used with caution in individuals who have kidney or liver disease . It is recommended that individuals with diabetes, thyroid disease , heart problems , and a history of stroke or high blood pressure discuss the use of this medication with their doctor. It is important to clear all medications with your doctor and pharmacist to make sure that you are not taking a medicine that could result in an adverse reaction when used with Afrin.