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If the exogenous anabolic steroid is stopped all of a sudden, the body can go into shock as the body’s own anabolic steroid production has been suppressed. The testes and the brain can take up to 2-4 weeks or even longer to recover. Thus, all users of anabolic steroids should limit the use of these drugs to a certain time period. In clinical medicine, anabolic steroids are administered for a period of 4-6 weeks and then a wash out phase is undertaken to allow for the testes and the pituitary gland to recover. If the anabolic steroids are taken for much longer period, one can permanently suppress the testes and its functions. Other problems related to suppression of the HPA pathway include heart disease, liver dysfunction and complete failure of the testes. In such cases, one has to take testosterone for the rest of life.

Due to a wide range of media coverage and large scale steroid scandals fans and experts have continued to bring the games integrity into question. Major League Baseball is a game of statistics. The entirety of a player's career is based upon the consistency and credibility of the numbers and accolades acquired during the period in which they played. "Their real impact has been at the margins: There are certainly some scrubs who wouldn't be in the majors without the juice, and we have ample evidence that at the other end of the scale, drugs can take Hall of Famers and all-time greats and help them perform at historically unprecedented levels" (La-Times). When it comes to this topic generally there are two trains of thought. Many do not see the harm with this type of substance use because it makes the game more exciting and allows athletes to reach untested potentials. On the other side of the argument many fans and experts believe the game has lost its purity because of this drug use. More recently an issue has arose with high-caliber players who have tested positive for performance-enhancing drugs are not being voted for on a hall of fame ballot. This fact has brought many to question the game's integrity. No matter the statistics and achievements produced by the certain player prior to drug use, a positive test for steroids has shown to discredit the athletes integrity and career entirely.

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