Nasal-Delivery Decongestants . Nasal-delivery decongestants are applied directly into the nasal passages with a spray, gel, drops, or vapors. Nasal decongestants come in long-acting or short-acting forms. The effects of short-acting decongestants last about 4 hours; long-acting decongestants last 6 - 12 hours. The active ingredients in nasal decongestants include oxymetazoline, xylometazoline, and phenylephrine. Nasal forms work faster than oral decongestants and may not cause as much drowsiness. However, they can cause dependency and rebound.
There were 12,679 eligible patients (651 MM; 2285 MAT; 9743 AM). Compared with the reference cohort AM, during the 3- to 30-day postindex period, lower adjusted odds (p < ) of having one or more rhinosinusitis-related medical encounters was observed for MM (odds ratio [OR] = ; 95% CI, -) and MAT (OR = ; 95% CI, -); having one or more rhinosinusitis-related prescriptions for MM (OR = ; 95% CI, -) and MAT (OR = ; 95% CI, -); having one or more antibiotic, nasal steroid, or oral steroid prescriptions for MM (OR = ; 95% CI, -) and MAT (OR = ; 95% CI, -); and having one or more antibiotic prescriptions for MM (OR = ; 95% CI, -) and MAT (OR = ; 95% CI, (-).