Steroid suppositories for proctitis

Transdermal patches can be a very precise time released method of delivering a drug. Cutting a patch in half might affect the dose delivered. The release of the active component from a transdermal delivery system (patch) may be controlled by diffusion through the adhesive which covers the whole patch, by diffusion through a membrane which may only have adhesive on the patch rim or drug release may be controlled by release from a polymer matrix. Cutting a patch might cause rapid dehydration of the base of the medicine and affect the rate of diffusion.

Methotrexate is given weekly as an intramuscular injection of 15 to 25 mg. Side effects are rare and include leukopenia and hypersensitivity interstitial pneumonitis. Hepatic fibrosis is the most severe potential sequela of long-term therapy. Patients with concomitant alcohol abuse and/or morbid obesity are more likely to develop hepatic fibrosis and therefore should not be treated with methotrexate. It is prudent to obtain a baseline chest radiograph and to monitor complete blood count, liver function and renal function every two weeks until the patient is receiving oral therapy, and every one to three months thereafter. Before methotrexate therapy is initiated, the risks of treatment and the possible need for a liver biopsy should be discussed with the patient.

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      Progesterone is a steroid hormone secreted in women by the corpus luteum and the follicle in normal menstruation, and by the placenta in pregnancy. It is also synthesised by the testes and adrenal cortex in small amounts.

Steroid suppositories for proctitis

steroid suppositories for proctitis

      Progesterone is a steroid hormone secreted in women by the corpus luteum and the follicle in normal menstruation, and by the placenta in pregnancy. It is also synthesised by the testes and adrenal cortex in small amounts.

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